This biotech start-up is working overtime to develop a second-wave, mutation-resistant Covid-19 vaccine

In March 2020, Hannu Rajaniemi pivoted his biotech firm Helix Nanotechnologies’ focus from most cancers therapies to Covid-19 vaccines.

Rajaniemi’s then-six-person start-up wasn’t going to find a way to compete with the likes of Pfizer and AstraZeneca, however HelixNano, because it’s recognized, had a totally different aim: Create a higher, second-generation vaccine in opposition to the novel coronavirus.

“We need to keep going and develop more countermeasures — more broadly effective second-wave vaccines, therapeutics and tests. … The virus is very good at generating surprises,” Rajaniemi says.

Today, HelixNano has 9 staff and Rajaniemi says its new vaccine will go to scientific trials in 2021, with the potential for approval by early 2022, relying “on a lot of factors.”

Helix Nanotechnologies staff working within the lab in Cambridge, Mass. “Given that we’ve been working at a furious pace, it’s been very important to find space to actually think and reflect and make sure our team is working on the most important problem at any given time,” Rajaniemi says.

Photo courtesy Helix Nanotechnologies.

The function biotech start-ups can play in a pandemic

Rajaniemi initially co-founded Helix Nanotechnologies in Cambridge, Massachusetts in 2013 to develop most cancers therapeutics, which was a private mission: His mom acquired sick with and finally handed due to metastatic breast most cancers.

When the corporate pivoted to working on Covid-19 vaccines, he knew his start-up would not be one of many first vaccines out of the gate.

“That would have required billions in [Operation] Warp Speed funding,” Rajaniemi says. (HelixNano has acquired $6.four million in whole funding as of May, in accordance to Crunchbase, from traders together with Y Combinator, and has acquired grant cash from Google billionaire Eric Schmidt’s Schmidt Futures.)

“In this crisis, the role of a start-up is to pursue more technically challenging, second-generation approaches and find solutions that the less agile bigger players might miss,” he says.

While the primary wave of Covid vaccines distributed within the United states from Pfizer/BioNTech, Moderna and Johnson & Johnson have to adapt their vaccines to new strains, HelixNano’s booster vaccine is designed to “provide much broader immunity,” he says.

“The reason we got into this … was that we were worried about mutated SARS-CoV-2 strains able to evade vaccine immunity,” Rajaniemi says. “That is precisely the state of affairs that is now taking part in out with the South African, Brazilian and different rising variants.”

New vaccine applied sciences: Essentially ‘a zoom operate and an amplify operate’

Developing a vaccine that is resistant to virus mutations is “an extremely challenging problem technically,” Rajaniemi says.

But with the benefit of having the ability to construct on all of the data scientists now have in regards to the virus, HelixNano invented “two completely new vaccine technologies” for which they’ve filed for patents, in accordance to Rajaniemi.

“Essentially, we have a ‘zoom’ function and an ‘amplify’ function for mRNA vaccines,” he says. (Both the Pfizer-BioNTech and Moderna vaccines are mRNA expertise, as is Helix Nanotechnologies’ booster.)

“We can make vaccines both more targeted and more powerful than was previously possible,” says Rajaniemi.

The first expertise Helix Nanotechnologies developed makes vaccines extra correct.

“Traditional vaccines are blunt instruments. You show the immune system a bit of the virus — like the spike protein that SARS-CoV-2 uses to infect cells — and [the body] generates antibodies against it,” Rajaniemi says. And “those antibodies are essentially random.”

However, HelixNano’s new expertise directs antibodies at a very particular a part of the virus’ spike protein that “matters the most for preventing infection,” in accordance to Rajaniemi.

“To use a nerdy analogy, imagine the virus is the Death Star [space station from Star Wars]. To blow it up you need to hit a very small target — the thermal exhaust port,” says Rajaniemi (who is additionally a printed science fiction writer).

“Your X-Wings [starfighters] could just randomly fire at the whole Death Star, but you would have to get very, very lucky to destroy it,” he says.

“But if you concentrate all your fire on the exhaust port, you have a much better chance — even if your shots get less accurate as the virus mutates.” 

The second vaccine expertise HelixNano developed is a method to multiply the physique’s immune response to a particular vaccine goal by a issue of 100.

“For us as a company and for the biotech as a whole, the pandemic has squeezed an entire decade of development into 12 months,” says Rajaniemi.

Photo credit score: Helix Nanotechnologies

Taken collectively, these two technological advances are what HelixNano has used to construct their Covid-19 mutation-resistant booster vaccine.

Beyond its personal vaccine expertise improvements, HelixNano is additionally collaborating with Louis Falo’s lab at University of Pittsburgh to make a vaccine expertise that may be utilized to the pores and skin, fairly than by a shot, which due to this fact might be self-administered.

“The mRNA platform has proven to be effective for vaccination, but does have limitations including the requirement for very low temperatures (cold-chain) across the storage, delivery, and deployment process,” says Falo, who is chairman of the dermatology division on the University of Pittsburgh and a bioengineering professor.

“We imagine an mRNA vaccine that is stable at room temperature and can therefore be readily deployed in global vaccination campaigns the same way that one would distribute and apply Band-Aids.”

(Separately, Falo’s lab has its personal pores and skin software vaccine known as PittCoVacc, which has submitted preclinical information to the Food and Drug Administration as a Pre-Investigational New Drug Application software.) 

Beyond Covid

Such broadly protecting and simply administrable vaccines may play a roll in getting extra of the greater than 7.7 billion folks folks on the earth immunized. Even because the U.S. vaccination efforts transfer alongside — as of March 29, 143 million vaccine doses have been administered, in accordance to the Center for Disease Control and Prevention — many different international locations efforts are lagging by orders of magnitude.

But the work HelixNano is doing could have implications past Covid-19, too. The expertise the start-up has created can be utilized to develop different vaccines past Covid, Rajaniemi says.

“Just like we took some of the technologies we developed in a cancer context — like rapid mRNA manufacturing — and applied them to Covid, the Covid work has taught us how to develop an entirely new class of personalized cancer vaccines,” Rajaniemi says.

“We’re still 95% on Covid, but are starting to spin the cancer work back up.”

“For us as a company and for the biotech as a whole, the pandemic has squeezed an entire decade of development into 12 months,” Rajaniemi says.

Correction: This story has been corrected to replicate the collaboration between Helix Nanotechnologies and Louis Falo’s lab considerations an mRNA vaccine that may be utilized to the pores and skin fairly than injected.

See additionally:

What it is like to invent a coronavirus vaccine in the course of a pandemic

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