First Covid-19 reinfection documented in Hong Kong, researchers say

Researchers in Hong Kong on Monday reported what seems to be the primary confirmed case of Covid-19 reinfection, a 33-year-old man who was first contaminated by SARS-CoV-2 in late March after which, 4 and a half months later, seemingly contracted the virus once more whereas touring in Europe.

The case raises questions in regards to the sturdiness of immune safety from the coronavirus. But it was additionally met with warning by different scientists, who questioned the extent to which the case pointed to broader considerations about reinfection.

There have been scattered reviews of instances of Covid-19 reinfection. Those reviews, although, have been based mostly on anecdotal proof and largely attributed to flaws in testing.

But in this case, researchers on the University of Hong Kong sequenced the virus from the affected person’s two infections and located that they didn’t match, indicating the second an infection was not tied to the primary. There was a distinction of 24 nucleotides — the “letters” that make up the virus’ RNA — between the 2 infections.

“This is the world’s first documentation of a patient who recovered from Covid-19 but got another episode of Covid-19 afterwards,” the researchers stated in a press release.

Experts cautioned that this affected person’s case may very well be an outlier among the many tens of hundreds of thousands of instances all over the world and that immune safety could typically last more than just some months. They stated that ongoing research monitoring sufferers who had recovered from Covid-19 would assist attain extra definitive conclusions.

“There’s been more than 24 million cases reported to date,” Maria Van Kerkhove, a coronavirus knowledgeable on the World Health Organization, stated at a briefing Monday, when requested in regards to the Hong Kong paper. “And we need to look at something like this at a population level.”

The query of how lengthy somebody is protected from Covid-19 after being contaminated and recovering looms giant.

Studies are more and more discovering that most individuals who get better from the sickness mount a sturdy immune response involving each antibodies (molecules that may block the virus from infecting cells once more) and T cells (which will help clear the virus). This has advised that individuals can be protected against one other case for some period of time.

But based mostly on what occurs with different coronaviruses, consultants knew that immunity to SARS-CoV-2 wouldn’t final without end. People typically turn out to be prone once more to the coronaviruses that trigger the widespread chilly after a yr and even much less, whereas safety in opposition to SARS-1 and MERS seems to final for just a few years.

“What we are learning about infection is that people do develop an immune response, and what is not completely clear yet is how strong that immune response is and for how long that immune response lasts,” Van Kerkhove stated. She added she was nonetheless reviewing the Hong Kong case.

The power and sturdiness of the immune response can be a vital issue in how lengthy vaccines will likely be efficient for, and for a way usually folks would possibly want a booster dose.

In the Hong Kong case, the person had traveled to Spain and returned to Hong Kong through the United Kingdom. A saliva pattern was taken upon arrival in Hong Kong as a part of a screening protocol and examined constructive for SARS-CoV-2 on Aug. 15.

During his second an infection, the person didn’t have any signs. Some sufferers undergo their course of Covid-19 with out exhibiting signs, however researchers have additionally hypothesized that secondary instances of the coronavirus will typically be milder than the primary. Even if immune programs cannot cease the virus from infecting cells, they may nonetheless rally some stage of response that retains us from getting sicker. During his first case, the affected person had basic Covid-19 signs of cough, fever, sore throat, and headache.

Experts stated it was additionally vital to contemplate the immune response the affected person generated after his first an infection. While most individuals appear to mount a strong response, there was indication that some folks don’t produce neutralizing antibodies — these that may block the virus from infecting cells — at very excessive ranges, for unclear causes.

“The fact that somebody may get reinfected is not surprising,” stated Malik Peiris, a virologist on the University of Hong Kong, who will not be an creator of the paper describing the reinfection however is aware of the case. “But the reinfection didn’t cause disease, so that’s the first point. And the second thing is that it is important to know whether the patient mounted a neutralizing antibody response to the first infection or not. Because the vast majority of patients in our experience do mount a good neutralizing antibody response. So is this person an outlier or is he likely to be the average person infected?”

Even if the Hong Kong case is an outlier, it factors to some implications: For one, individuals who have recovered from Covid-19 also needs to be vaccinated, the researchers stated. And they need to proceed following precautions like carrying a masks and bodily distancing.

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